Topics
Eight themes, derived from the concept tags in the ten papers rather than from a preset ontology. 115 raw tags collapsed to 34 canonical concepts, then grouped.
Resistosome architecture and oligomeric state
What activated NLRs build, and how much that varies. Pentamer, hexamer, octamer, undecamer and stalled sub-hexameric intermediates all appear in this corpus, so stoichiometry is a measurement, not a clade property.
4 papers
Sensor-helper communication in NLR networks
How expanded sensor NLRs signal through a small number of helper executors, and what holds the pairing specificity in place.
6 papers
Calcium signalling and where immunity is executed
Resistosomes as ion channels, and the growing evidence that which membrane they act on is itself a functional variable.
4 papers
Effector suppression of NLR function
Pathogen effectors that target the receptors themselves rather than downstream immunity, and the structural basis of how they do it.
2 papers
Effector recognition and its evolution
How receptors acquire and change what they detect, including integrated decoys and the mimicry alternative.
3 papers
Autoinhibition and priming
What keeps a receptor off until it is wanted: resting-state conformation, N-terminal extensions, transcript isoform, and surface-receptor licensing.
7 papers
Evolution of NLR repertoires
How NLR families expand, contract, subfunctionalise and specialise across lineages and tissues.
9 papers
Engineering receptors
Moving interfaces, swapping domains and reprogramming specificity, in every case guided by a structure.
6 papers
Sources
data/taxonomy.json- Concept reconciliation in
data/reconciliation.json